139404-48-1
- Product Name：Tiotropium Bromide monohydrate
- Molecular Formula：C19H22BrNO4S2.xH2O
- Purity：99%
- Molecular Weight：472.424
Product Details;
CasNo： 139404-48-1
Molecular Formula： C19H22BrNO4S2.xH2O
Quality Manufacturer Supply Wholesale Tiotropium Bromide monohydrate 139404-48-1 Best Price
- Molecular Formula:C19H22BrNO4S2.xH2O
- Molecular Weight:472.424
- Melting Point:218-220oC
- PSA：124.77000
- LogP:-0.75580
Tiotropium Bromide monohydrate (Cas 139404-48-1) Usage
|
Description |
Tiotropium bromide monohydrate is a medication used as a bronchodilator for the treatment of lung diseases, particularly asthma and chronic obstructive pulmonary disease (COPD). |
| Mechanism of Action | Long-acting muscarinic antagonist (LAMA) |
| Forms | Tiotropium bromide monohydrate is available as a soft mist inhaler. |
| Administration | Typically administered through a soft mist inhaler. |
| Uses | Administered as a long-term, once-daily maintenance bronchodilator treatment. |
139404-48-1 Relevant articles
AN IMPROVED PROCESS FOR PREPARATION OF SCOPINE HYDROBROMIDE
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Page/Page column 15, (2021/07/02)
The present invention relates to an effi...
Preparation method of tiotropium bromide
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Paragraph 0075-0077, (2021/08/19)
The invention provides a preparation met...
PROCESS FOR SYNTHESIS OF TIOTROPIUM BROMIDE MONOHYDRATE
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, (2018/09/19)
Provided herein is a process for synthes...
A PROCESS FOR PREPARING TIOTROPIUM BROMIDE AND INTERMEDIATES THEREOF
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, (2018/04/20)
Provided herein is a process for synthes...
139404-48-1 Process route
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- 1336913-22-4
7-(2,2-dithiophen-2-ylacetoxy)-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide
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- 139404-48-1
tiotropium bromide
Conditions
| Conditions | Yield |
|---|---|
|
With oxygen; triethylamine; In acetonitrile; at 20 ℃; for 48h;
|
74% |
|
With oxygen; In acetonitrile; at 20 ℃; for 48h;
|
74% |
|
With oxygen; triethylamine; In acetonitrile; at 20 ℃; for 48h;
|
74% |
-
-
N-methylsconinium hexafluorophosphate
-
- 26447-85-8
hydroxy-di-thiophen-2-yl-acetic acid methyl ester
-
- 139404-48-1
tiotropium bromide
Conditions
| Conditions | Yield |
|---|---|
|
N-methylsconinium hexafluorophosphate; hydroxy-di-thiophen-2-yl-acetic acid methyl ester; With potassium tert-butylate; In acetone; at 0 ℃; for 20 - 24h; Zeolite of type 4A;
With lithium bromide; In acetone; Product distribution / selectivity;
|
87.7% |
|
N-methylsconinium hexafluorophosphate; hydroxy-di-thiophen-2-yl-acetic acid methyl ester; With potassium tert-butylate; In acetone; at 0 ℃; for 20 - 24h; Molecular sieve;
With lithium bromide; In acetone; Product distribution / selectivity;
|
87.7% |
|
N-methylsconinium hexafluorophosphate; hydroxy-di-thiophen-2-yl-acetic acid methyl ester; With potassium tert-butylate; zeolite Na12Al12Si12O48*nH2O 4 ?; In acetone; at 0 ℃;
With lithium bromide; In acetone; Product distribution / selectivity;
|
87.7% |
|
N-methylsconinium hexafluorophosphate; hydroxy-di-thiophen-2-yl-acetic acid methyl ester; With potassium tert-butylate; In acetone; at 0 ℃; for 4h; Molecular sieve;
With lithium bromide; In acetone; Product distribution / selectivity;
|
48% |
|
N-methylsconinium hexafluorophosphate; hydroxy-di-thiophen-2-yl-acetic acid methyl ester; With dmap; In acetone; for 24h; Molecular sieve; Heating / reflux;
With lithium bromide; In acetone; Product distribution / selectivity;
|
35% |
|
N-methylsconinium hexafluorophosphate; hydroxy-di-thiophen-2-yl-acetic acid methyl ester; In acetone; for 50 - 70h; Heating / reflux; Molecular sieve;
With lithium bromide; In acetone; Product distribution / selectivity;
|
30% |
139404-48-1 Upstream products
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136310-64-0
N-demethyltiotropium
-
74-83-9
methyl bromide
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411207-31-3
tiotropium bromide monohydrate
-
26447-85-8
hydroxy-di-thiophen-2-yl-acetic acid methyl ester
Relevant Products
-
Tiotropium BromideCAS：136310-93-5
-
Tetrapeptide-5CAS：883220-97-1
-
DofetilideCAS：115256-11-6
