503068-34-6
- Product Name：Vilanterol
- Molecular Formula：C24H33Cl2NO5
- Purity：99%
- Molecular Weight：486.436
Product Details;
CasNo： 503068-34-6
Molecular Formula： C24H33Cl2NO5
Buy High Quality 99% Pure Vilanterol 503068-34-6 Cheap Price
- Molecular Formula:C24H33Cl2NO5
- Molecular Weight:486.436
- Boiling Point:646.7±55.0 °C(Predicted)
- PKA:9.99±0.20(Predicted)
- PSA：91.18000
- Density:1 +-.0.06 g/cm3(Predicted)
- LogP:4.99900
Vilanterol (Cas 503068-34-6) Usage
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Description |
Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity, primarily used for the once-daily treatment of chronic obstructive pulmonary disease (COPD) and asthma. |
| Mechanism of Action | Vilanterol is a long-acting beta-agonist that relaxes and opens the air passages in the lungs. |
| Safety Considerations | Vilanterol may increase the risk of heart and blood vessel problems, including changes in heart rhythm. |
| Uses | Vilanterol, as a LABA, plays a significant role in improving respiratory function and managing conditions like COPD and asthma when used in combination with other bronchodilators. |
503068-34-6 Relevant articles
In Vitro Pharmacological Characterization of Vilanterol, a Novel Long-Acting β2-Adrenoceptor Agonist with 24-Hour Duration of Action
Robert J. Slack, Victoria J. Barrett, Valerie S. Morrison, Richard G. Sturton, Amanda J. Emmons, Alison J. Ford and Richard G. Knowles
, Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 218-230;
From these investigations, the data for vilanterol are consistent, showing that it is a novel, potent, and selective β2-AR receptor agonist with a long duration of action. This pharmacological profile combined with clinical data is consistent with once a day dosing of vilanterol in the treatment of both asthma and chronic obstructive pulmonary disease (COPD).
AN IMPROVED PROCESS FOR PREPARATION OF VILANTEROL OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
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, (2021/02/26)
The invention discloses an improved proc...
Preparation method of vilanterol and salt thereof
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, (2020/11/02)
The invention relates to a preparation m...
503068-34-6 Process route
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C24H31Cl2NO6
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![4-[(1R)-2-({6-[(2-{[(2,6-dichlorophenyl)methyl]oxy}ethyl)oxy]-hexyl}-amino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol](/upload/2023/11/e3cc64de-9a27-49a2-afa9-983e7be11c13.png)
- 503068-34-6
4-[(1R)-2-({6-[(2-{[(2,6-dichlorophenyl)methyl]oxy}ethyl)oxy]-hexyl}-amino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol
| Conditions | Yield |
|---|---|
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With sodium tetrahydroborate; boron trifluoride diethyl etherate; In tetrahydrofuran; at 0 ℃; for 4.66667h; Inert atmosphere; Reflux;
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88% |
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![(R)-2-{6-[2-(2,6-dichlorobenzyloxy)ethoxy]hexylamino}-1-(2 ,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)ethanol succinate](/upload/2023/11/e101084a-be19-4983-a6e8-0c440f4d3bcd.png)
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(R)-2-{6-[2-(2,6-dichlorobenzyloxy)ethoxy]hexylamino}-1-(2 ,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)ethanol succinate
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- 503068-34-6
4-[(1R)-2-({6-[(2-{[(2,6-dichlorophenyl)methyl]oxy}ethyl)oxy]-hexyl}-amino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol
| Conditions | Yield |
|---|---|
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With sulfuric acid; In tetrahydrofuran; at 5 - 20 ℃; for 4h; Solvent; Reagent/catalyst;
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503068-34-6 Upstream products
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54030-34-1
1-(2,2-dimethyl-4H-benzo[d][1,3]dioxan-6-yl)ethanone
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102293-80-1
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
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452339-70-7
di-(tert-butyl) 2-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-oxoethyliminodicarbonate
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452339-71-8
tert-butyl 2-(2,2-dimethyl-4H-1,3-benzodioxane-6-yl)-2-carbonylethylcarbamate
503068-34-6 Downstream products
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503070-59-5
4-[(1R)-2-({6-[(2-{[(2,6-dichlorophenyl)methyl]oxy}ethyl)oxy]-hexyl}-amino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol α-phenylcinnamate
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503070-58-4
4‐{(1R)‐2‐[(6‐{2‐[(2,6‐dichlorobenzyl)oxy]ethoxy}hexyl)amino]‐1‐hydroxyethyl}‐2‐(hydroxymethyl)phenol triphenylacetate
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