73874-95-0
- Product Name：4-N-BOC-Aminopiperidine
- Molecular Formula：C10H20N2O2
- Purity：99%
- Molecular Weight：236.742
Product Details;
CasNo： 73874-95-0
Molecular Formula： C10H20N2O2
Appearance： Off-white solid
Factory Supply High Purity 99% Pure 4-N-BOC-Aminopiperidine 73874-95-0 Efficient Delivery
- Molecular Formula:C10H20N2O2
- Molecular Weight:236.742
- Appearance/Colour:Off-white solid
- Vapor Pressure:0.000854mmHg at 25°C
- Melting Point:162-166 °C
- Boiling Point:304.8 °C at 760 mmHg
- PKA:12.39±0.20(Predicted)
- Flash Point:138.2 °C
- PSA：50.36000
- Density:1.02 g/cm3
- LogP:1.98280
4-N-Boc-aminopiperidine(Cas 73874-95-0) Usage
|
Description |
4-(N-Boc-amino)piperidone may be used as a functionalization reagent for introduction of a primary and a tertiary amino group to poly(2-isopropyl-2-oxazoline. It can also be used as pharma building block. It is used in the synthesis of a piperidine-4-carboxamide CCR5 antagonist with potent anti-HIV 1-activity. It is an intermediate for the synthesis of various pharmaceutical and biologically active compounds, including inhibitors and therapeutic agents. It is used for the synthesis of diphenyl purine derivatives as peripherally selective cannabinoid receptor 1 Antagonists. |
|
Chemical Properties |
off-white crystalline powder |
|
Uses |
Pharma building block. |
|
General Description |
4-(N-Boc-amino)piperidone is a piperidone derivative. |
InChI:InChI=1/C10H20N2O2/c1-10(2,3)14-9(13)12-8-4-6-11-7-5-8/h8,11H,4-7H2,1-3H3,(H,12,13)/p+1
73874-95-0 Relevant articles
Design and development of novel thiazole-sulfonamide derivatives as a protective agent against diabetic cataract in Wistar rats via inhibition of aldose reductase
Yin, Liang,Zhang, Mingxue,He, Tiangeng
, p. 63 - 70 (2021/10/01)
In recent years, ALR2 (aldose reductase)...
Substituted 2-thioxothiazolidin-4-one derivatives showed protective effects against diabetic cataract via inhibition of aldose reductase
Huang, Wanrong,Zhang, Yue,Liang, Xu,Yang, Lichun
, (2020/04/07)
In an effort to develop a new class of p...
Catalytic Transfer Hydrodebenzylation with Low Palladium Loading
Yakukhnov, Sergey A.,Ananikov, Valentine P.
supporting information, p. 4781 - 4789 (2019/09/16)
A highly-efficient catalytic system for ...
Method for preparing 4-Boc-aminopiperidine
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Paragraph 0024; 0026; 0027; 0029; 0030; 0032; 0033; 0035, (2018/04/15)
The invention discloses a method for pre...
73874-95-0 Process route
-
-
73889-19-7
tert-butyl (1-benzylpiperidin-4-yl)carbamate
-
-
73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester
| Conditions | Yield |
|---|---|
|
With
hydrogen;
palladium 10% on activated carbon;
In
methanol;
for 12h;
|
99% |
|
With
hydrogen;
palladium 10% on activated carbon;
In
methanol;
for 12h;
|
99% |
|
With
hydrogen;
palladium on activated charcoal;
In
methanol;
for 18h;
under 2585.74 Torr;
|
97% |
|
With
hydrogen;
palladium on carbon;
In
methanol;
at 20 ℃;
|
96% |
|
With
hydrogen;
palladium on activated charcoal;
In
methanol;
at 20 ℃;
|
95% |
|
With
hydrogenchloride; 10 wt% Pd(OH)2 on carbon; water; hydrogen;
In
methanol;
|
94% |
|
With
cyclohexene;
palladium dihydroxide;
In
ethanol;
for 3.5h;
Heating;
|
92% |
|
With
palladium 10% on activated carbon; ammonium formate;
In
methanol;
at 65 ℃;
for 2h;
Reflux;
|
85% |
|
With
formic acid; potassium hydroxide;
In
ethanol;
at 70 ℃;
for 1h;
|
81% |
|
With
hydrogen;
palladium 10% on activated carbon;
In
ethanol;
at 20 ℃;
for 16h;
|
76% |
|
With
hydrogen;
palladium 10% on activated carbon;
In
methanol;
for 18h;
under 2585.81 Torr;
|
|
|
With
hydrogen;
palladium 10% on activated carbon;
In
tetrahydrofuran; ethanol;
|
|
|
palladium-carbon;
In
ethanol;
|
|
|
palladium;
In
ethanol;
|
2.87 g (14.4 mmol, 91.4%) |
|
palladium;
In
methanol;
|
|
|
palladium on charcoal;
In
methanol;
|
|
|
With
sodium hydroxide; sodium chloride; ammonium formate;
palladium on charcoal;
In
methanol; hexane; water;
|
|
|
With
hydrogen;
palladium 10% on activated carbon;
In
ethanol;
at 20 ℃;
for 24h;
|
|
|
With
hydrogen;
palladium 10% on activated carbon;
In
ethanol;
at 40 ℃;
|
|
|
With
palladium 10% on activated carbon; hydrogen;
In
ethanol;
|
|
|
With
palladium 10% on activated carbon; hydrogen;
In
methanol;
for 24h;
|
|
|
With
acetic acid;
palladium-carbon catalyst;
In
methanol;
|
|
|
With
hydrogen;
palladium 10% on activated carbon;
In
methanol;
for 18h;
under 2585.81 Torr;
|
-
-
C17H24N2O2
-
-
73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester
| Conditions | Yield |
|---|---|
|
With
palladium 10% on activated carbon; hydrogen;
In
methanol;
at 70 ℃;
for 4h;
under 6000.6 - 7500.75 Torr;
Reagent/catalyst;
Temperature;
|
90.7% |
73874-95-0 Upstream products
-
73889-19-7
tert-butyl (1-benzylpiperidin-4-yl)carbamate
-
159874-20-1
1-benzyloxycarbonyl-4-tert-butoxycarbonylaminopiperidine
-
50541-93-0
4-amino-1-benzylpiperidine
-
24424-99-5
di-tert-butyl dicarbonate
73874-95-0 Downstream products
-
135632-30-3
benzyl (2R)-3-<1-<<4-<(tert-butyloxycarbonyl)amino>piperidinyl>carbonyl>-2-benzyl>propionate
-
150544-85-7
benzyl (2RS)-2-benzyl-3-<
-
150544-82-4
(4S)-4-benzyl-3-<(2R)-3-<1-<4-<(tert-butyloxycarbonyl)amino>piperidinyl>>carbonyl>-2-<(1-naphthyl)methyl>oxazolidin-2-one
-
323578-34-3
tert-butyl N-[1-[(4-nitrophenyl)methyl]-4-piperidyl]carbamate
Relevant Products
-
1-(4-Methylphenyl)-2-nitropropeneCAS：29816-55-5
-
N-Carbethoxy-4-piperidoneCAS：29976-53-2
-
4-PIPERIDINECARBOXYLIC ACID T-BUTYL ESTER HCLCAS：892493-65-1
