What is the N-[2-[Bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxamide hydrochloride?

N-[2-[Bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxamide hydrochloride is , while it's Molecular Formula is C21H30N4O5S.HCl. Acotiamide Hydrochloride is an acetylcholinesterase inhibitor which has been shown to stimulate gastric motility and improve gastric motility dysfunction in rats (1,2). Acotiamide Hydrochloride has also been shown to improve meal-related symptoms of functional dyspepsia.

What is the CAS number for N-[2-[Bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxamide hydrochloride?

The CAS number of N-[2-[Bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxamide hydrochloride is 185104-11-4.

What is N-[2-[Bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxamide hydrochloride (185104-11-4) used for?

Acotiamide Hydrochloride (YM-443, Z-338) is the hydrochloride salt form of acotiamide, a prokinetic agent with gastrointestinal (GI) motility-enhancing activity. It is a new orally active selective acetylcholinesterase inhibitor. Although the exact mechanism by which acotiamide exerts its effect has yet to be fully elucidated, this agent appears to inhibit acetylcholinesterase (AchE), an enzyme responsible for the breakdown of acetylcholine (Ach). Increased Ach concentrations lead to an improvement of gastric emptying and GI motility and eventually to a reduction of dyspepsia symptoms.

What is the N-[2-[Bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxamide hydrochloride?

N-[2-[Bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxamide hydrochloride is , while it's Molecular Formula is C21H30N4O5S.HCl. Acotiamide Hydrochloride is an acetylcholinesterase inhibitor which has been shown to stimulate gastric motility and improve gastric motility dysfunction in rats (1,2). Acotiamide Hydrochloride has also been shown to improve meal-related symptoms of functional dyspepsia.

What is the CAS number for N-[2-[Bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxamide hydrochloride?

The CAS number of N-[2-[Bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxamide hydrochloride is 185104-11-4.

What is N-[2-[Bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxamide hydrochloride (185104-11-4) used for?

Acotiamide Hydrochloride (YM-443, Z-338) is the hydrochloride salt form of acotiamide, a prokinetic agent with gastrointestinal (GI) motility-enhancing activity. It is a new orally active selective acetylcholinesterase inhibitor. Although the exact mechanism by which acotiamide exerts its effect has yet to be fully elucidated, this agent appears to inhibit acetylcholinesterase (AchE), an enzyme responsible for the breakdown of acetylcholine (Ach). Increased Ach concentrations lead to an improvement of gastric emptying and GI motility and eventually to a reduction of dyspepsia symptoms.

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185104-11-4

Product Name：Acotiamide HCl
Molecular Formula：C21H30N4O5S.HCl
Purity：99%
Molecular Weight：487.01

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Product Details;

CasNo： 185104-11-4

Molecular Formula： C21H30N4O5S.HCl

Factory Supply Hot Sale Acotiamide HCl 185104-11-4 Competitive Price

Molecular Formula:C21H30N4O5S.HCl
Molecular Weight:487.01
PSA：148.24000
LogP:4.72760

185104-11-4 Relevant articles

Preparation method of acotiamide hydrochloride impurity

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Paragraph 0022; 0024, (2020/08/02)

The invention discloses a preparation me...

Industrial production method of acotiamide hydrochloride

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Paragraph 0040-0043, (2019/06/07)

The invention discloses an industrial pr...

IMPROVED METHOD FOR MANUFACTURING ACOTIAMIDE

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Paragraph 0029, (2019/06/20)

PROBLEM TO BE SOLVED: To provide a metho...

Acotiamide hydrochloride preparation method

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Paragraph 0056; 0057; 0058; 0059; 0060; 0061, (2017/02/09)

The invention discloses an acotiamide hy...

185104-11-4 Process route

: 185106-16-5
Acotiamide

: 185104-11-4
2-[N-(4,5-dimethoxy-2-hydroxybenzoyl)amino]-4-[(2-diisopropyl-aminoethyl)aminocarbonyl]-1,3-thiazole hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; In isopropyl alcohol; butan-1-ol; for 4h; pH=1 - 2; Cooling with ice;	89.7%
With hydrogenchloride; In water; isopropyl alcohol; at 80 - 85 ℃; for 1h; Large scale;	82.3%
With hydrogenchloride; In water; isopropyl alcohol; at 5 ℃; for 1h;	78%
With hydrogenchloride; In methanol; water; at 15 - 25 ℃; for 0.5h; pH=< 1; Time;	5.7 g

: 877997-99-4
2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylic acid methyl ester

: 121-05-1
N',N'-diisopropyl-ethane-1,2-diamine

: 185104-11-4
2-[N-(4,5-dimethoxy-2-hydroxybenzoyl)amino]-4-[(2-diisopropyl-aminoethyl)aminocarbonyl]-1,3-thiazole hydrochloride

Conditions

Conditions	Yield
2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylic acid methyl ester; N',N'-diisopropyl-ethane-1,2-diamine; In toluene; at 100 ℃; for 5h; With hydrogenchloride; In water; isopropyl alcohol;	97%
2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylic acid methyl ester; N',N'-diisopropyl-ethane-1,2-diamine; In 1,4-dioxane; at 75 ℃; for 6h; Inert atmosphere; With hydrogenchloride; In methanol; water;	96.3%

185104-11-4 Upstream products

877997-99-4
2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylic acid methyl ester
121-05-1
N',N'-diisopropyl-ethane-1,2-diamine
67-63-0
isopropyl alcohol
71-36-3
butan-1-ol

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